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I'm not sure I could answer the question "mobile first" vs "desktop first" in how I work. I think in layers. Page layout is usually around layer 3 of 5, & a small fraction of the overall CSS. While doing layout, I resize constantly.
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Media queries generally build on top of simpler defaults, in the fashion of a mobile-first. I think that's often what people mean? But my code/approach doesn't progress from one screen size to another. Every step involves constant resizing - not defined by specific devices.
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Is this common, or do many people actually design one viewport size or device ratio at a time?